DEVELOPS GAS-BASED TECHNOLOGIES TO PRESERVE AND TRANSPORT VIABLE CELLS, TISSUES AND ORGANS
MISSION
Our Goal
To make transplantation accessible and effective — regardless of time or distance
Why It Matters
We believe every patient should have a chance to live when it matters most
We believe that every human in a need of an organ transplant should be able to get it immediately.
Limenbio Inc. is a biomaterial preservation technology company. Our r&d started in 2011 with successful experimental preservation of skin grafts and erythrocytes in a gas mixture for a period of 30 days. As people age, the wear and tear on individual organs—such as the heart, lungs, liver, or kidneys—becomes a limiting factor, outpacing the body's overall ability to sustain longevity.
To achieve this a significant enhancement of the organ preservation and delivery is required to withstand both organ deterioration and logistical challenges.
We develop cost efficient and reliable organ preservation technology and device that allow dramatic increase procurement distance with no load on organ quality.An erosional remnant is a persisting rock formation that remains after extensive wind, water, and/or chemical erosion. To the untrained eye, it may appear to be visually like a glacial erratic, but instead of being transported and deposited, it was carved from the local bedrock. Many good examples of erosional remnants are seen in Karlu Karlu/Devils Marbles Conservation Reserve in the Northern Territory of Australia. - A pedestal rock, also known as a rock pedestal or mushroom rock, is not a true balancing rock, but is a single continuous rock form with a very small base leading up to a much larger crown. Some of these formations are called balancing rocks because of their appearance. The undercut base was attributed for many years to simple wind abrasion, but is now believed to result from a combination of wind and enhanced chemical weathering at the base where moisture would be retained longest. Some pedestal rocks sitting on taller spire formations are known as hoodoos.
To achieve this a significant enhancement of the organ preservation and delivery is required to withstand both organ deterioration and logistical challenges.
We develop cost efficient and reliable organ preservation technology and device that allow dramatic increase procurement distance with no load on organ quality.An erosional remnant is a persisting rock formation that remains after extensive wind, water, and/or chemical erosion. To the untrained eye, it may appear to be visually like a glacial erratic, but instead of being transported and deposited, it was carved from the local bedrock. Many good examples of erosional remnants are seen in Karlu Karlu/Devils Marbles Conservation Reserve in the Northern Territory of Australia. - A pedestal rock, also known as a rock pedestal or mushroom rock, is not a true balancing rock, but is a single continuous rock form with a very small base leading up to a much larger crown. Some of these formations are called balancing rocks because of their appearance. The undercut base was attributed for many years to simple wind abrasion, but is now believed to result from a combination of wind and enhanced chemical weathering at the base where moisture would be retained longest. Some pedestal rocks sitting on taller spire formations are known as hoodoos.
CURRENT STATUS
2010
First grant for gas preservation concept
First grant for gas preservation concept
Funding from IPF to develop schematics for gaseous preservation of viable cell grafts
2011
Prototype for tissue and cell experiments
Prototype for tissue and cell experiments
Equipment built for testing small tissue samples and cell suspensions
2012
Experimental preservation in gas
Experimental preservation in gas
Preservation of various cells in a gas mixture tested experimentally
Limenbio Inc. founded
Company established with funding from a local innovation center
2013
Collaboration with Aalborg University
Collaboration with Aalborg University
Electron microscopy confirms feasibility of preserving stem cells and RBCs in a modified gas atmosphere
2014
Second grant and upgraded equipment
Second grant and upgraded equipment
Limenbio Inc. receives a second round of funding from IPF and develops next-generation preservation hardware
2015
RBCs and skin grafts preserved in gas
RBCs and skin grafts preserved in gas
Preservation of red blood cells and skin grafts demonstrated; results presented at international scientific meetings
2016
Thesis on gas preservation defended
Thesis on gas preservation defended
Alexander Ponomarev successfully defends his dissertation on gas-based preservation methods
2017
Two patents obtained
Two patents obtained
Official patents granted for core developments in gas-based preservation technology
2018
International publication released
International publication released
Summary of RBC and stem cell preservation experiments published in Cryo-Letters
2019
Rat heart preserved and transplanted
Rat heart preserved and transplanted
11-hour preservation followed by successful heterotopic transplantation at Shumakov National Research Center
2020
Pilot study on rats’ heart preservation
Pilot study on rats’ heart preservation
Followed by Langendorff evaluation at Almazov National Research Center
2022
First funding round from Kamaflow VC
First funding round from Kamaflow VC
Money obtained from VC Kamaflow
2023
Huge leap in scalability for large organs
Huge leap in scalability for large organs
New capacious and smart equipment developed; new patents pending
2024
Pilot study on rabbit lung preservation
Pilot study on rabbit lung preservation
Ex-vivo evaluation at First Pavlov Medical University, Saint Petersburg
Pilot study on pig heart preservation
8.5 hours of preservation at Meshalkin’s Center
We are looking for
Partnership in transplantological area to run further experiments/preclinical trials
