HIPPER
Biopôle Lausanne, Switzerland

Extending donor heart viability from 4 hours to 12+

HIPPER is a sealed, autonomous preservation system designed to keep donor hearts viable for longer, simply and reliably.
We are looking for partners: transplant centres for our next studies, MedTech investors, and regulatory and reimbursement experts.
Our vision

Where you live should not determine whether you live.

Today a donor heart can travel only as far as four hours allow. We are building the technology to keep it viable for longer, so a heart can reach the right patient, wherever that patient is.

Too few donor hearts reach the patients who need them

64 million
people live with heart failure
2×
expected growth in cases by 2030
1 in 3
eligible donor hearts is discarded, largely because of transport and logistics constraints
Sources: Global Public Health Burden of Heart Failure, PMC 2023; HFSA Heart Failure Statistics 2025; Review of Global Activity of Heart Transplant, Circulation: Heart Failure 2025.

Why today's options fall short

Supply is scarce

A transplant is the only cure for end-stage heart failure, yet donor hearts are few and cases are rising.

Cold storage is short

An ice box keeps a heart for about 4 hours, which limits how far a donor heart can travel.

Warm perfusion is complex

Machines that keep the heart beating extend the window, but they are bulky, need specialist staff and are costly to run.
Preservation window
Static cold storage
≈ 4 hours
HIPPER, in animal studies
12+ hours
Our solution: HIPPER

A third way between the ice box and the heart-in-a-box machine

HIPPER keeps the heart cold while actively supporting it inside a sealed chamber. The system runs by itself during transport, so transplant teams can focus on the patient.
Longer. 12+ hours of heart preservation in our animal studies, versus about 4 hours on ice.
Simpler. A closed, autonomous system designed for any transplant team to use.

Tested against the standard of care, and published

91.7%
vs 73.1%
Pressure recovery: pig hearts after 8 hours of HIPPER outperformed hearts after 4 hours of cold storage.
American Journal of Transplantation, 2026
15 of 15
vs 4 of 10
Rat hearts resuscitated after 6 hours with HIPPER, versus after cold storage.
Pathophysiology, 2025

Help us bring HIPPER to the clinic

We are looking for transplant centres as study partners, regulatory and reimbursement experts, and investors with MedTech experience.

15 years of research, step by step

From cells and tissues to whole hearts in large animals.
2010
Research on our preservation approach begins
2015
Red blood cells and skin grafts preserved for 30 days
2019
First rat heart preserved and transplanted
2025
Rat heart study published in Pathophysiology
2026
Pig heart study published in the American Journal of Transplantation
A Swiss company

Built in the Swiss life sciences ecosystem

Limenbio Sàrl is based at Biopôle, the life sciences campus in Lausanne. Our medical advisor, Prof. Piergiorgio Tozzi, is a cardiac surgeon and former deputy chief at CHUV, Lausanne University Hospital.
Based at Biopôle Lausanne
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